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Investigation on the transmission dynamics, evolution and zoonotic potential of C. difficile infection in pet-human interfaces

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Ecology and Evolution of Infectious Diseases (EEID)

Project Information in NIH RePORTER

Investigation on the transmission dynamics, evolution and zoonotic potential of C. difficile infection in pet-human interfaces

Principal Institution

Iowa State University

Principal Investigator(s) (PI)

Mooyottu, Shankumar

Project Contact Information

Email: shaan@iastate.edu

Year(s) Awarded

2022–2027

NIH Partners

NIAID

Project Description

The research is creative and original as it represents the first systematic study addressing community-associated Clostridioides difficile infections (CDI) in the pet-human interface by bringing together the expertise in human medicine, veterinary medicine, microbiology, epidemiology, mathematical modeling, genomics, and artificial intelligence. The results from this project are expected to provide the epidemiologic, genomic, and social basis for pet-borne transmission of CDI.

The outcome of this project could vertically advance our understanding of how pets contribute to the burden of CDI incidence in humans. This would yield critical information for developing preventive strategies against community-associated CDI transmission. Thus, built upon the One Health approach, the proposed research addresses the ecological, evolutionary, and social drivers influencing the transmission dynamics of CDI in the community.