Investigation on the transmission dynamics, evolution and zoonotic potential of C. difficile infection in pet-human interfaces
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Ecology and Evolution of Infectious Diseases (EEID)
Project Information in NIH RePORTER
Investigation on the transmission dynamics, evolution and zoonotic potential of C. difficile infection in pet-human interfaces
Principal Institution
Iowa State University
Principal Investigator(s) (PI)
Mooyottu, Shankumar
Project Contact Information
Email:
shaan@iastate.edu
Year(s) Awarded
2022–2027
NIH Partners
NIAID
Project Description
The research is creative and original as it represents the first systematic study addressing community-associated Clostridioides difficile infections (CDI) in the pet-human interface by bringing together the expertise in human medicine, veterinary medicine, microbiology, epidemiology, mathematical modeling, genomics, and artificial intelligence. The results from this project are expected to provide the epidemiologic, genomic, and social basis for pet-borne transmission of CDI.
The outcome of this project could vertically advance our understanding of how pets contribute to the burden of CDI incidence in humans. This would yield critical information for developing preventive strategies against community-associated CDI transmission. Thus, built upon the One Health approach, the proposed research addresses the ecological, evolutionary, and social drivers influencing the transmission dynamics of CDI in the community.