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Full Award: Molecular principles of neuronal maturation and integration in the adult and aging brain

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Global Brain Disorders Research

Project Information in NIH RePORTER

Molecular principles of neuronal maturation and integration in the adult and aging brain

Principal Institution

Harvard University

Principal Investigator(s) (PI)

Arlotta, Paola; Schinder, Alejandro Fabian

Project Contact Information

Email: paola_arlotta@harvard.edu

Year(s) Awarded

2018-2023

Country

Argentina

Collaborators

Fundacion Instituto Leloir

NIH Partners

NINDS

Project Description

The overarching goal of this project is to understand the molecular mechanisms underlying activity-dependent maturation of new grandule cells (GCs) in the adult and aging brain, combining strategies for transcriptional profiling and bioinformatic analysis developed by the Arlotta lab and the functional studies developed by the Schinder lab, to build an experimental pipeline for the discovery of new molecules controlling circuit plasticity that includes assays for testing the roles of individual proteins to an unprecedented level of molecular and functional detail.

Related World Regions / Countries

Western Hemisphere