Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis
Principal Institution
Stellenbosch University Tygerberg Campus
Principal Investigator(s) (PI)
du Preez, Karen
Project Contact Information
Email: karen_dupreez@sun.ac.za
Year(s) Awarded
2020-2025
Country
South Africa
Project Description
Despite tuberculosis (TB) being a treatable and preventable disease, recent modeling work estimated that nearly 200,000 children <5 years died of TB during 2015, making it one of the top ten causes of death in children under 5 years globally. Unreliable and incomplete surveillance data for children with TB is a key challenge that currently limits our ability to appropriately manage children with this disease, including those suffering from severe forms such as TB meningitis (TBM) who experiences high mortality and often lifelong disability. This project will use interdisciplinary methods, including modelling and spatial analyses, to provide critical information on the burden, incidence and related mortality of TBM in children at a global, national and sub-national level in South Africa, whilst identifying opportunities to improve prevention and care through in- depth prospective surveillance.
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