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Effect of Community Wide Deworming on Hookworm Modulated Immune Responses to Bystander Antigens and Vaccines in Southern India
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Effect of Community Wide Deworming on Hookworm Modulated Immune Responses to Bystander Antigens and Vaccines in Southern India
Principal Institution
Christian Medical College
Principal Investigator(s) (PI)
Ajjampur, Sitara Swarna Rao
Project Contact Information
Email:
sitararao@cmcvellore.ac.in
Year(s) Awarded
2020–2025
Country
India
Project Description
Community-wide deworming to significantly reduce and/or break transmission of soil-transmitted helminths (parasitic worms) can reverse the effects of these infections on host immune responses (or how people's bodies recognize and defend themselves against bacteria, viruses, and substances that appear foreign and harmful). This study will look at the effect of large-scale, community-wide deworming with albendazole on both adults and children, and whether this effect will be sustained in the post deworming period. This study will demonstrate the potential additional benefits of deworming and is of particular importance to communities with a high burden of hookworm infection.
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