Host Defense Against Shigella Flexneri
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Host Defense Against Shigella Flexneri
Principal Institution
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)
Principal Investigator(s) (PI)
Noor, Zannatun
Project Contact Information
Email: zannatun@icddrb.org
Year(s) Awarded
2019–2024
Country
Bangladesh
Collaborators
University of Virginia
Project Description
Annually, there are approximately 270 million reported or confirmed cases of cases worldwide, predominantly in low-income countries, with more than 200,000 of these resulting in death, especially in children under five years of age (5). Very recently, Shigella ranked the highest among the overall pathogen burden, with particularly high incidence in the second year of life (10). We propose for advancement of the understanding of host response to Shigella flexneri infection to lay the foundation for developing potential host-targeted treatment for this highly antibiotic-resistant bacterium.
Related World Regions / Countries