Psychosocial Distress, Inflammatory Reactivity and Central Sensitization in the Pathway to HIV-Related Pain: Characterizing the Associations and Developing a Pragmatic, Coping-Focused Intervention
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Psychosocial Distress, Inflammatory Reactivity and Central Sensitization in the Pathway to HIV-Related Pain: Characterizing the Associations and Developing a Pragmatic, Coping-Focused Intervention
Principal Institution
University of Cape Town
Principal Investigator(s) (PI)
Madden, Victoria Joy
Project Contact Information
Email: tory.maddden@uct.ac.za
Year(s) Awarded
2019–2024
Country
South Africa
Collaborators
Brigham and Women's Hospital
Project Description
HIV-related pain is under-recognised, distressing, poorly understood, and difficult to treat, yet clarifying the mechanistic pathways underlying HIV-related pain would inform treatment development. This project will study the relationships between psychosocial distress, inflammatory reactivity, central sensitization, and HIV-related pain and develop a pragmatic, coping-focused interventions to decrease distress and pain in people with HIV. This research is of considerable public health importance to countries with high and low burdens of HIV because it stands to inform treatments to decrease HIV-related pain and thus relieve the considerable strain that HIV-related pain places on healthcare services.
Related World Regions / Countries
Related Global Health Research Topics