Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit 
         cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at 
         opm.gov.
				
		
					Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
				
	
				
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
				
						Funding Fogarty Program
					HIV-associated Noncommunicable Diseases Research at LMIC Institutions
				
					
						Project Information in NIH RePORTER
						
							Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
						
					
						Principal Institution
						
							Stellenbosch University
						
					
						Principal Investigator(s) (PI)
						
							Decloedt, Eric Hermann; Orrell, Catherine 
						
					
						Project Contact Information
						Email: 
ericdecloedt@sun.ac.za
					
					
						Year(s) Awarded
						
							2023–2025
						
					
						Country
						
							South Africa
						
					
					
						NIH Partners
						
							OD/NIH
						
					
						Project Description
						The risk for stroke is two-fold higher in people with HIV (PWH) compared to people without HIV, despite antiretroviral therapy (ART) and viral suppression, and without many of the traditional stroke risk factors, suggesting ongoing HIV-associated inflammation as a potential driver of stroke risk. Adherence to ART sufficient to suppress viral loads to below the clinically-relevant threshold of 200 copies/mL may not be adequate to suppress viremia completely, with ongoing HIV-associated inflammation.
This project will conduct a comparative observational study in virally suppressed PWH presenting with stroke compared to PWH without stroke to obtain preliminary, exploratory data on the association between stroke and imperfect adherence to ART, viremia and the viral reservoir, and exploratory proteomic biomarkers.
		
					
							Related World Regions / Countries
						
			
					
							Related Global Health Research Topics