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Molecular Genetic Etiology of Craniosynostosis among Ghanaians (MoGECaG)
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Global Noncommunicable Diseases and Injury Research
Project Information in NIH RePORTER
Molecular Genetic Etiology of Craniosynostosis among Ghanaians (MoGECaG)
Principal Institution
Kwame Nkrumah University of Science and Technology
Principal Investigator(s) (PI)
Gowans, Lord Jephthah Joojo; Cunningham, Michael L; Obiri-Yeboah, Solomon
Project Contact Information
Email: ljj.gowans@gmail.com
Year(s) Awarded
2020-2023
Country
Ghana
Collaborators
Seattle Children’s Craniofacial Center
University of Washington
Project Description
This project aims to carry out the first ever genetic etiology studies on craniosynostosis in a sub- Saharan African population, Ghana, which is highly underrepresented in genetic etiology studies. This project will build research capacity in craniosynostosis in Ghana and carry out whole exome sequencing and RNA-sequencing on saliva and cranial bone samples, respectively, obtained from Ghanaian patients with craniosynostosis. The project has both basic science and translational relevance: identification of population-specific etiologic genetic variants and/or genes for craniosynostosis and high-risk families – these are necessary for genetic counseling.
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