Fogarty Funding Concepts

​Concepts represent early planning stages for program announcements, request for applications, or solicitations for Fogarty Advisory Board input. Clearance of a concept by Fogarty's Advisory Board does not guarantee it will become an initiative.

Updated October 1, 2018

Concepts

September 2018

May 2017

September 2018

Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43) and International Research Training Planning Grants (D71)

Purpose/Goals and Objectives: To support the training of LMIC researchers in critical areas of HIV/AIDS prevention, treatment, care and cure continuum; to enhance research capacity building efforts at the LMIC institution; to build a network of researchers both within and across LMICs to collaborate and share unique resources; and to develop the scientific strengths to find a global solution to end the AIDS epidemic.

Background/Rationale: The Fogarty HIV Research Training (HIVRT) Program originated from a consolidation of the AIDS International Training and Research Program (AITRP) and the International Clinical, Operations and Health Services Research Training Award for AIDS and TB Program (ICOHRTA-HIV/TB). These programs were designed to strengthen the capacity of institutions in LMICs to conduct HIV-related research on the evolving HIV epidemic in their country. Over the last 30 years, the training program has produced a generation of LMIC scientists who are leading the research efforts in their home countries. With success in the treatment options and prevention approaches, life expectancy in people living with HIV (PLWH) has increased. Simultaneously, about 2 million new infections per year continue to fuel the transmission of HIV. There is a disproportionate benefit of access to treatment and care across the various PLWH communities, and a disproportionate spread in the incidence of new infections across the various age groups at a global level. The increased longevity of PLWH has coincided with a plethora of age-related morbidities that are exacerbated in HIV infection. Increased reliance on drugs has underscored the importance of understanding the pharmacology of drug-drug interactions and nutritional requirements for effective treatment. These are just some of the reasons to continue training efforts and to maintain a research workforce in the LMIC that will be poised to take on new and emerging challenges.

Prior FIC Initiatives: The most recent predecessors for the currently proposed initiatives expired in August 2018. These are:

  • Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43 Clinical Trial Optional) - PAR-18-717
  • International Research Training Planning Grants (D71) - PAR-16-281

Overview of the Proposed Program: The overall goal of this program is to continue the Fogarty mission of supporting and facilitating global health research partnerships between U.S. and LMIC institutions in training the next generation of LMIC scientists to combat HIV/AIDS. This program is designed to focus each individual training award on specific research capacity building at one or within a regional network of LMIC institutions. The D43 mechanism is for applications to support research training programs that are expected to develop and strengthen the scientific leadership and expertise needed for HIV-related research at LMIC institutions. Continued training in basic, clinical, translational, and epidemiological research is still needed to address emerging issues. While all areas of research of public health importance to the LMIC are welcome, emerging research areas that represent significant scientific gaps include: a) HIV and coinfections and comorbidities including non-communicable diseases (NCDs); b) behavioral and social sciences research including stigma and discrimination; c) understanding HIV positive key populations, at risk adolescents and young children; d) HIV associated disorders in the aging population including mental health and dementia; and e) research on implementation of effective public health measures to decrease transmission and incidence of new infections across the populations. The D71 mechanism will support planning for a D43 training grant for those looking to start new training programs.

Relevance to FIC Strategic Plan: The proposed initiatives support several of FIC’s strategic goals and serves as an important conduit to build the much-needed HIV/AIDS research workforce. It builds research capacity through individuals, institutions and networks to meet future and evolving global health challenges (Goal 1); supports research and research training in implementation science (Goal 3); and builds and strengthens partnerships to advance global health research and research capacity (Goal 5).

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Infrastructure Development Training Programs for Critical HIV Research at Low-and Middle-Income Country (LMIC) Institutions (G11)

Purpose/Goals and Objectives: The overall goal is to enhance and sustain research capacity building efforts at the LMIC Institutions to address the HIV epidemic in their countries through supporting the training of LMIC researchers and administrators in critical infrastructure areas.

Background/Rationale: The Fogarty HIV Research Training Program is designed to strengthen the ability of institutions in LMICs to conduct HIV-related research on the evolving HIV/AIDS epidemics in their country. To accomplish this goal, it is necessary to provide training a) in research support areas necessary for the execution of research programs, b) in managing and maintaining grants and c) to be competitive for research funding.

Prior FIC Initiatives: The previous FOA, listed below, ended in August 2018.

Infrastructure Development Training Programs for Critical HIV Research at Low-and Middle-Income Country Institutions (G11) - PAR-16-280

Overview of the Proposed Program: Research infrastructure training programs will maximize previous investments and further strengthen the LMIC institution's research capabilities by providing more accessible research infrastructure training opportunities to candidates in their own country and in other LMICs. The G11 mechanism will support applications from U.S. and LMIC institutions for infrastructure development training programs to achieve technical, administrative and financial management expertise required for one of several research infrastructure functions considered critical to a successful high-quality research environment. These are: a) research administration and management, b) research integrity oversight, c) ethical review of research for the protection of human subjects, d) laboratory animal welfare oversight, e) health sciences library and information services, f) information and communications technology systems (ICT) for research, g) biostatistics and data analysis, h) technology transfer and intellectual property protection, and i) any area not mentioned above that justifiably will contribute to enhancing Institutional services that can support research activities. The awards may be requested for a duration of up to 3 years. The budget can be up to $100,000 (total costs) per year.

Relevance to FIC Strategic Plan: The proposed initiative supports several of FIC’s strategic goals. It builds research capacity through individuals, institutions and networks to meet future and evolving global health challenges (Goal 1). It stimulates innovation in the development and implementation of technologies and other locally relevant solutions to address global health problems (Goal 2). It builds and strengthens partnerships to advance global health research and research capacity (Goal 5).

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Emerging Global Leader Award

Purpose: To support the career development of early-career LMIC investigators under the mentorship of U.S. and LMIC investigators, leading to independent research careers at LMIC institutions.

Background: Opportunities for investigators from low- and middle-income countries (LMICs) to establish independent global health research careers are critical to building a robust global health workforce, but the mentored research experiences that foster research independence can be difficult to obtain. FIC’s longstanding International Research Scientist Development Award (IRSDA; K01) program has been instrumental in launching successful independent global health research careers of U.S. investigators, but foreign applicants are not eligible for NIH K01 awards. In 2015, FIC launched a similar program for LMIC investigators based at LMIC institutions. The Emerging Global Leader Award provides support for early-career LMIC scientists to conduct mentored research and career development activities. Enthusiasm for this program across the NIH is reflected in the number of Institutes, Centers, and Offices (ICOs) participating in the program by signing on to the funding announcement and co-funding awards. To date, the program has supported 19 awards in six countries (South Africa, Uganda, Pakistan, Nigeria, Kenya and Bangladesh), covering a wide range of research topics, and with nearly half of the awards receiving co-funds from other ICOs. The expectation is that through this sustained period of research and career development, LMIC investigators will launch research careers at their LMIC institutions and become competitive for independent and collaborative research support with U.S. scientists.

Prior FIC Initiative: Continuation of Emerging Global Leader Award (K43) PAR-17-001.

Overview of the Proposed Program:

  • The Emerging Global Leader Award provides three to five years of salary support and research support to an early career research scientist from an LMIC for an intensive, mentored research career development experience.
  • The candidate must hold a junior faculty position at an LMIC academic or research institution and may not have been the PI of a multi-year independent research grant (e.g., R01-equivalent) or a career development award equivalent to the NIH K awards.
  • During the award period, recipients are expected to increase their capabilities in advanced research methodology, analysis and data management, research administrative skills, responsible conduct of research, scientific presentation, and manuscript and grant writing.
  • Applicants should propose critically needed career development activities and research projects highly relevant to the health priorities of their country. These activities should propel awardees to become competitive principal investigators for new research project grant funding.
  • The research activities should take place primarily in the LMIC.
  • The career development award is expected to lead to an independently funded research career at the LMIC institution or in another LMIC.
  • The broader goals of the program are to ensure a career pathway for promising LMIC scientists, to strengthen the intellectual capacity of global health research at foreign institutions, and to foster long-lasting research collaborations.

Relevance to FIC Strategic Plan: By supporting early-career LMIC scientists as they transition to independent global health research careers at their home institutions, the Emerging Global Leader Award program will develop strong collaborators for U.S.-supported global health research. This supports several of FIC’s strategic goals and fills an important career development need.

May 2017

Role of Stigma in HIV/AIDS Prevention, Treatment and Care in Low- and Middle- Income Countries

For the published request for applications, see the September 1, 2017 NIH Guide announcement, Reducing Stigma to Improve HIV/AIDS Prevention, Treatment and Care in Low and Middle- Income Countries (R21) (PAR-17-474).

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