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Fogarty Funding Concepts

Concepts represent early planning stages for program announcements, request for applications, or solicitations for Fogarty Advisory Board input. Clearance of a concept by Fogarty's Advisory Board does not guarantee it will become an initiative.

Updated September 16, 2019

Concepts

September 2019

Global Infectious Disease Research Training Program (D43)

Background and Rationale: Infectious diseases continue to impose a tremendous health burden in resource-poor countries throughout the world, claiming millions of lives annually and inflicting severe morbidity that results in significant losses in economic productivity and social progress. Attempts to control infectious diseases endemic to low- and middle-income countries (LMICs) suffer due to an incomplete understanding of the pathogens, disease manifestations and transmission mechanisms, inadequate preventive measures and interventions, and insufficient health services and disease control efforts. A major barrier to improved treatment and control of infectious diseases is the lack of capacity to conduct locally relevant infectious disease research often due to the scarcity of scientists and health professionals in LMICs with relevant research expertise. Therefore, the overall intent of the Global Infectious Disease Research Training Program is to engender scientific knowledge and skills that will enhance capacity at LMIC institutions to conduct research directly related to prevention, treatment and control of infectious diseases causing major morbidity and mortality. Applications that include countries with little current research capacity will be especially encouraged.

The specific objectives of the Global Infectious Disease Research Training Program are:

  • To develop research training opportunities and career development activities for a cadre of LMIC scientists and health research professionals to strengthen the capacity to conduct independent, sustainable infectious disease research at a LMIC institution in collaboration with a U.S. research institution.
  • To provide mentored training-related infectious disease research experience that is directly relevant to the health priorities of the LMIC.
  • To strengthen the capabilities of trainees at LMIC institutions to lead, manage and train others in infectious disease research.

Prior Initiatives: In 2003, FIC consolidated the requirements for non-HIV/AIDS infectious disease research-training programs under a single program announcement (PAR-03-012). These RFA-based programs included International Training and Research in Emerging Infectious Diseases (ITREID); Actions for Building Capacity in Support of International Centers for Infectious Disease Research (ABC/ICIDR); Tuberculosis International Training and Research; and International Malaria Research Training. The program announcement was reissued in FY2018 to include the new clinical trials requirements (PAR-18-840) and previously as PAR-17-057, PAR-14-193, PAR-10-260, PAR-08-154 and PAR-05-128. A companion program announcement (PAR 19-362), Planning Grant for Global Infectious Disease Research Training Program (D71), provides support for LMIC applicants to develop full research training program applications for this program.

Overview of Re-issued Program: Awards will support up to 5 years of mentored advanced research training (postdoctoral, degree and non-degree) for multiple trainees within an U.S.-LMIC collaboration. Each research training program should provide:

  • A strong foundation in research design, methods, and analytic techniques appropriate for the proposed infectious disease research area;
  • Jointly mentored experience conducting infectious disease research using state-of-the-art methods as well as opportunities for trainees to present and publish their research findings; and
  • Career enhancement skills (i.e. scientific writing & presentation, grant writing, data management, good clinical practice, biosafety, English as second language).

Relevance to FIC Strategic Plan:

Goal 1: Build research capacity through individuals, institutions and networks to meet future and evolving health challenges.

Strategic Priorities:

Eligibility: U.S. institutions are eligible to apply with collaborating LMIC institutions and LMIC institutions are eligible to apply with collaborating U.S. institutions. Each PD/PI must be designated as the PD/PI of at least one research award that is directly relevant to the scientific focus of the research training proposed and with at least 18 months of support remaining at the time of submission of the application.

Reissue Global Brain and Nervous System Disorders Research across the Lifespan (GLOBAL BRAIN) FOAs (R21, R01)

Proposal: The Global BRAIN program was established in 2002 to address the burden of neurological disorders across the lifespan in low- and middle-income countries (LMICs). The program is configured as two related trans-NIH announcements, a R21 planning/exploratory grant and a R01 application to a partner IC. As of 2018, 165 R21s and 61 R01s representing 41 LMICs were awarded. The current FOAs have one more 2019 receipt date. We propose to reissue program FOAs for another three years starting in 2020.

Purpose:

  1. Support research on nervous system development, function, health and impairment (neuro-health) at any life stage or across the lifespan on topics relevant to LMICs;
  2. Build neuro-health research capacity among LMIC partners and institutions involved in a specific research project;
  3. Encourage initiatives that lead to appropriate and innovative diagnostics, prevention, and treatment strategies;
  4. Encourage collaboration among LMIC institutions;
  5. Promote career development of young LMIC investigators in neuro-health related research.

Eligibility: Domestic and foreign institutions are eligible to apply for both the R21 and R01 FOAs. Applications must be submitted as collaborations between institutions in at least 2 different countries: a U.S. OR an Upper-Middle Income Country (UMIC) with a LMIC (including UMIC-UMIC collaborations). The R01 is intended to provide an investigator with the opportunity to further develop collaborative pilot research conducted in the LMIC countr(ies), so the scientist submitting an R01 may either have a previous R21 under this program or alternatively, show strong evidence of an ongoing research collaboration with strong global health infrastructure being developed at the LMIC institution(s). Furthermore, the research proposed in the R01 must coincide with the research interests of a participating partner organization or partner NIH IC, as FIC co-funds but does not routinely award the R01.

Priority Areas: Target research areas include broadly nervous system function, behavior, neuro-health and disease across the lifespan, including for example, neurological, neuropsychiatric, addictive, neuro-developmental and neurodegenerative diseases and disorders; and topics of special relevance in LMICs such as neuro-infectious diseases, neuro-trauma and seizure disorders. Research may cover impacts on individuals or populations at a certain life stage or across the lifespan. Researchers focusing on genetic, epigenetic and environmental drivers, factors that affect healthy brain development and aging, health care delivery, and socio-economic factors are also encouraged. Applications may focus across the spectrum of research types: basic, epidemiological, clinical, health services, translational and implementation research. Lab, human, animal and population-based studies are all accepted. As an option, applicants are also encouraged to leverage research collaboration networks within a specific diseases or disorder-related topical area to build enhanced in-country and regional research capacity.

May 2019

HIV-associated Non-Communicable Diseases (NCDs) Research at Low- and Middle-Income Country (LMIC) Institutions

For the published request for applications, see the NIH Guide announcement HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional) (PAR-20-030), published October 18, 2019

February 2019

Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth)

Purpose: To support the development of institutions in low- and middle-income countries (LMICs) that serve as regional hubs for collaborative research, data management, training, curriculum and outreach material development, and policy support around high-priority local, national and regional environmental and occupational health threats; and to support a global network of hubs that serves as a platform for coordinated research and training activities in environmental and occupational health.

Background: The World Health Organization (WHO) estimates that in 2012, 12.6 million deaths globally, representing 23% of all deaths, were attributable to the environment, and that 22% of the global burden of disease is due to the environment (1). Meanwhile, more than two million workers around the world die each year due to occupational injury or illness, and 317 million people suffer from work related injuries, costing the global economy billions of dollars (2). The burden is highest in LMICs, particularly in Africa, Southeast Asia and the Western Pacific. Although LMICs suffer more from environmental and occupational hazards, in many cases, inadequate capacity exists to study and mitigate these problems.

The Global Environmental and Occupational Health (GEOHealth) Hub program originated from a reengineering of the Fogarty International Center’s (FIC’s) long-standing International Training and Research in Environmental and Occupational Health (ITREOH) program. The ITREOH program provided research training to nearly 200 scientists at 34 institutions in 43 countries. Because of this breadth, there was less investment in any one program or LMIC institution. The goal of the new GEOHealth program was to develop a handful of regional science hubs, based in LMICs, that would become internationally-recognized centers for environmental and occupational health research, ideally serving the multinational regions in which they reside (3).

In 2015, FIC funded seven GEOHealth Hubs in partnership with the National Cancer Institute (NCI), the National Institute of Environmental Health Sciences (NIEHS), the National Institute for Occupational Safety and Health (NIOSH), and Canada's International Development Research Centre (IDRC). The Global Alliance for Clean Cookstoves also participates in the program by offering supplemental funding. The GEOHealth Hubs are supported by two linked cooperative agreement awards, with a research award to the LMIC institution and a research training award to the US institution. To date, the GEOHealth program has 1) supported research on air pollution, electronic waste, agricultural health, neurotoxicants, climate change and occupational health, 2) provided research training to over 100 LMIC trainees, often directly associated with the research supported through the linked LMIC GEOHealth research award, 3) supported new degree programs in environmental health at LMIC institutions, 4) supported cross-network research and training activities, and 5) engaged local stakeholders and decision and policy makers through workshops and outreach efforts.

Continued development of LMIC-based hubs that conduct high-quality research, that train a research workforce with cutting-edge skills to understand and interpret environmental and occupational health threats, and that provide a means of engagement with decision and policy makers is essential for addressing existing challenges and to be poised to address emerging global environmental and occupational health challenges.

Prior FIC Initiatives:

  • RFA-TW-14-001: Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth) - Research (U01)
  • RFA-TW-14-002: Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth) - Research Training (U2R)

Overview of the Proposed Program: The GEOHealth program will continue to support the development of LMIC-based hubs through funding announcements inviting new and renewal linked applications. The program will continue to support hubs as linked awards with coordinated management -- a research award to an LMIC institution linked to a research training award to a U.S. institution, with other collaborating U.S. and LMIC institutions as “spokes”. GEOHealth Hubs are expected to bring together multiple disciplines to advance the pace of scientific discovery, initially in one focal environmental or occupational health area.

Relevance to FIC Strategic Plan: The GEOHealth program supports the research capacity building of individuals, their institutions, and regional and global GEOHealth networks, fostering a sustainable platform to address priority needs in environmental and occupational health (Goal 1). The program supports activities that bring researchers and policy makers together to enhance uptake of evidence in policy and practice (Goal 3). The program focuses on the growing burden of noncommunicable diseases (Goal 4). The structure of the program fosters institutional research and training collaborations and benefits from several funding partnerships across the NIH, HHS, and internationally (Goal 5).

Citations:

  1. Prüss-Ustün A, Wolf J, Corvalán C, Bos R and Neira M. 2016. Preventing disease through healthy environments: A global assessment of the burden of disease from environmental risks. World Health Organization. ISBN 978 92 4 156519 6. Accessed 7 February 2019.
  2. International Labor Organization. 2012. Estimating the Economic Costs of Occupational Injuries and Illnesses in Developing Countries: Essential Information for Decision-Makers. ISBN 978-92-2-127015-7. Accessed 7 February 2019.
  3. Rosenthal J, Jessup C, Felknor S, Humble M, Bader F, and Bridbord K. 2012. International Environmental and Occupational Health: From Individual Scientists to Networked Science Hubs. Am J Ind Med 55:1069-1077. Accessed 7 February 2019.

Mobile Health: Technology and Outcomes in Low- and Middle-Income Countries

For the published request for applications, see the NIH Guide announcement:

Global Infectious Disease (GID) Planning Grant (D71)

For the published request for applications, see the NIH Guide announcement:

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