Concepts represent early planning stages for program announcements, request for applications, or solicitations for
Fogarty Advisory Board input. Clearance of a concept by Fogarty's Advisory Board does not guarantee it will become an initiative.
Updated August 7, 2020
International Research Scientist Development Award (IRSDA)
Purpose: Reissue FIC’s core mentored global health career development for U.S investigators.
Background: Opportunities to advance global health research careers are central to building a global health workforce, yet it remains a challenge for researchers to establish independent international careers given the time spent away from their home institutions. Prolonged field experience is critical for global health research and for establishing research partnerships but obtaining this field experience can be difficult for junior scientists who are balancing administrative and teaching requirements. Since 1999, FIC’s International Research Scientist Development Award (IRSDA) program has addressed this tension and filled an important global health career development gap by supporting advanced postdoctoral scientists and junior faculty to prepare for independent research careers in global health. The program plays an important role in FIC’s suite of programs that increase human resource capacity in global health. FIC’s Research Training (D43) programs and the Fellows and Scholars program support career development at earlier stages of the career pipeline. The IRSDA program complements these by providing early career researchers opportunities to conduct mentored research in global health and to establish partnerships that strengthen global health research and lead to research independence.
The IRSDA, like other NIH mentored career development (K01) awards, fosters research independence through a period of mentored research and career development activities. FIC’s IRSDA is unique in its requirement that grantees spend 50% of their cumulative effort over the award period conducting research in a LMIC country, with a minimum of three months in any given year, and in its requirement that successful candidates are mentored by both a U.S. scientist and a LMIC scientist. These in-country and dual mentorship requirements help foster sustained collaborations and research capacity.
program evaluation concluded that the program has successfully developed a cadre of productive, independent global health researchers, as measured by the research published, the careers and collaborations established, and the subsequent funding secured. IRSDA grantees have worked in 33 countries across six world regions in an array of biomedical and behavioral science fields. Alumni have published over 1,500 peer-reviewed publications in range of biomedical fields. Through the program, FIC has built a community of U.S. global health researchers who are committed to confronting global health challenges, who understand the realities of conducting research in resource-limited settings, and who have formed long-lasting collaborative relationships with scientists around the world.
Prior FIC Initiative: PAR-18-539 and
Overview of Proposed Program: Continue the K01 program as currently configured with following modifications: 1) increase salary support available to $100,000, and 2) increase “Other Program Related Expenses” to $40,000. Although a candidate’s salary must be consistent with the salary structure of the institution, increasing the allowable salary better addresses the range of salary levels for non-clinical and clinical researchers. The Other Program-Related Expenses category supports research costs, travel, and career development costs, such as course fees. Increasing the allowable budget for this category supports the extensive travel required by the IRSDA K01.
Relevance to FIC Strategic Plan: By supporting early career scientists as they transition to independent global health research careers, the IRSDA program supports several of FIC’s strategic goals. The program builds research capacity to meet future and evolving global health challenges (Goal 1); through its in-country requirement, the program fosters partnerships with LMIC researchers and research institutions (Goal 5); projects focus on locally relevant solutions to address global health problems (Goal 2); and several projects have addressed implementation science (Goal 3) and the dual burden of communicable and noncommunicable disease (Goal 4).
Global Injury and Trauma Research Training Program (D43)
Purpose: Reissue FIC’s Global Injury and Trauma Research Training Program.
Background: According to the World Health Organization, over five million deaths every year, are caused by trauma and injury. Furthermore, over 90% of the injury-related deaths occur in low- and middle-income countries (LMICs), many due to lack of or limited access to quality emergency trauma care, rehabilitation services, absent or weak preventative policies, and working or living in unsafe conditions. Since 2005, the Fogarty International Center (FIC) and its partnering institutions (including NIH and non-NIH partners) have been supporting a collaborative program which seeks to create a cadre of researchers in LMICs capable to conduct research and research training related to the diagnosis, prevention and treatment of injury and trauma. Over the past three funding cycles, 21 awards were funded in six regions of the world: Sub-Saharan Africa, East Asia and Pacific, Middle East and North Africa, Latin America and the Caribbean, South Asia, and Europe and Central Asia.
Furthermore, a 2015 program evaluation concluded that the Trauma and Injury program has been successful in supporting scientific advances that are moving the field forward and building trauma and injury research capacity in LMICs. Evidenced by the changes in policies and preventive approaches in grantee countries, trauma grantees have built sustainable partnerships and centers devoted to trauma research and are continuing to expand the impact of the Trauma Program beyond their five-year grant funding cycles.
Additionally, the program has maintained an annual networking meeting, which brings together the grantees from this and other programs across the FIC (e.g., Ks and R21), engaged in the various aspects of trauma and injury research. This cross-pollination is anticipated to produce multi-disciplinary and multi-sectoral approaches, which are highly regarded as necessary components for the future of the field; and will engage more collaborators and critical stakeholders in order to catalyze use of evidence to inform programs and policy.
Prior FIC Initiative:
Overview of Proposed Program: Continue the D43 program as currently configured with the following modifications: 1) encourage proposals that focus on research during and in preparation for humanitarian and natural disasters as they impact trauma and injury in LMICs, and 2) require that resubmissions of programs that have completed 10 years under this grant, submit with the LMIC PI/Institution as primary applicant.
Relevance to FIC Strategic Plan: By supporting research capacity development of scientists through this D43 program, several FIC strategic goals are being answered. The program builds research capacity to meet future and evolving global health challenges (Goal 1); through in-country training and research, the program fosters partnerships with LMIC researchers and research institutions (Goal 5); and projects focus on locally relevant solutions to address trauma and injury issues and develop relevant policies (Goal 2).
Global Infectious Disease Research Training Program (D43)
For the published request for applications, see the NIH Guide announcement
Global Infectious Disease Research Training Program (D43 Clinical Trial Optional) (PAR-20-229), published June 10, 2020.
Reissue Global Brain and Nervous System Disorders Research across the Lifespan (GLOBAL BRAIN) FOAs (R21, R01)
Global BRAIN program was established in 2002 to address the burden of neurological disorders across the lifespan in low- and middle-income countries (LMICs). The program is configured as two related trans-NIH announcements, a R21 planning/exploratory grant and a R01 application to a partner IC. As of 2018, 165 R21s and 61 R01s representing 41 LMICs were awarded. The current FOAs have one more 2019 receipt date. We propose to reissue program FOAs for another three years starting in 2020.
- Support research on nervous system development, function, health and impairment (neuro-health) at any life stage or across the lifespan on topics relevant to LMICs;
- Build neuro-health research capacity among LMIC partners and institutions involved in a specific research project;
- Encourage initiatives that lead to appropriate and innovative diagnostics, prevention, and treatment strategies;
- Encourage collaboration among LMIC institutions;
- Promote career development of young LMIC investigators in neuro-health related research.
Eligibility: Domestic and foreign institutions are eligible to apply for both the R21 and R01 FOAs. Applications must be submitted as collaborations between institutions in at least 2 different countries: a U.S. OR an Upper-Middle Income Country (UMIC) with a LMIC (including UMIC-UMIC collaborations). The R01 is intended to provide an investigator with the opportunity to further develop collaborative pilot research conducted in the LMIC countr(ies), so the scientist submitting an R01 may either have a previous R21 under this program or alternatively, show strong evidence of an ongoing research collaboration with strong global health infrastructure being developed at the LMIC institution(s). Furthermore, the research proposed in the R01 must coincide with the research interests of a participating partner organization or partner NIH IC, as FIC co-funds but does not routinely award the R01.
Priority Areas: Target research areas include broadly nervous system function, behavior, neuro-health and disease across the lifespan, including for example, neurological, neuropsychiatric, addictive, neuro-developmental and neurodegenerative diseases and disorders; and topics of special relevance in LMICs such as neuro-infectious diseases, neuro-trauma and seizure disorders. Research may cover impacts on individuals or populations at a certain life stage or across the lifespan. Researchers focusing on genetic, epigenetic and environmental drivers, factors that affect healthy brain development and aging, health care delivery, and socio-economic factors are also encouraged. Applications may focus across the spectrum of research types: basic, epidemiological, clinical, health services, translational and implementation research. Lab, human, animal and population-based studies are all accepted. As an option, applicants are also encouraged to leverage research collaboration networks within a specific diseases or disorder-related topical area to build enhanced in-country and regional research capacity.
HIV-associated Non-Communicable Diseases (NCDs) Research at Low- and Middle-Income Country (LMIC) Institutions
For the published request for applications, see the NIH Guide announcement
HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional) (PAR-20-030), published October 18, 2019.
Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth)
Purpose: To support the development of institutions in low- and middle-income countries (LMICs) that serve as regional hubs for collaborative research, data management, training, curriculum and outreach material development, and policy support around high-priority local, national and regional environmental and occupational health threats; and to support a global network of hubs that serves as a platform for coordinated research and training activities in environmental and occupational health.
Background: The World Health Organization (WHO) estimates that in 2012, 12.6 million deaths globally, representing 23% of all deaths, were attributable to the environment, and that 22% of the global burden of disease is due to the environment (1). Meanwhile, more than two million workers around the world die each year due to occupational injury or illness, and 317 million people suffer from work related injuries, costing the global economy billions of dollars (2). The burden is highest in LMICs, particularly in Africa, Southeast Asia and the Western Pacific. Although LMICs suffer more from environmental and occupational hazards, in many cases, inadequate capacity exists to study and mitigate these problems.
The Global Environmental and Occupational Health (GEOHealth) Hub program originated from a reengineering of the Fogarty International Center’s (FIC’s) long-standing International Training and Research in Environmental and Occupational Health (ITREOH) program. The ITREOH program provided research training to nearly 200 scientists at 34 institutions in 43 countries. Because of this breadth, there was less investment in any one program or LMIC institution. The goal of the new GEOHealth program was to develop a handful of regional science hubs, based in LMICs, that would become internationally-recognized centers for environmental and occupational health research, ideally serving the multinational regions in which they reside (3).
In 2015, FIC funded seven
GEOHealth Hubs in partnership with the National Cancer Institute (NCI), the National Institute of Environmental Health Sciences (NIEHS), the National Institute for Occupational Safety and Health (NIOSH), and Canada's International Development Research Centre (IDRC). The Global Alliance for Clean Cookstoves also participates in the program by offering supplemental funding. The GEOHealth Hubs are supported by two linked cooperative agreement awards, with a research award to the LMIC institution and a research training award to the US institution. To date, the GEOHealth program has 1) supported research on air pollution, electronic waste, agricultural health, neurotoxicants, climate change and occupational health, 2) provided research training to over 100 LMIC trainees, often directly associated with the research supported through the linked LMIC GEOHealth research award, 3) supported new degree programs in environmental health at LMIC institutions, 4) supported cross-network research and training activities, and 5) engaged local stakeholders and decision and policy makers through workshops and outreach efforts.
Continued development of LMIC-based hubs that conduct high-quality research, that train a research workforce with cutting-edge skills to understand and interpret environmental and occupational health threats, and that provide a means of engagement with decision and policy makers is essential for addressing existing challenges and to be poised to address emerging global environmental and occupational health challenges.
Prior FIC Initiatives:
RFA-TW-14-001: Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth) - Research (U01)
RFA-TW-14-002: Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth) - Research Training (U2R)
Overview of the Proposed Program: The GEOHealth program will continue to support the development of LMIC-based hubs through funding announcements inviting new and renewal linked applications. The program will continue to support hubs as linked awards with coordinated management -- a research award to an LMIC institution linked to a research training award to a U.S. institution, with other collaborating U.S. and LMIC institutions as “spokes”. GEOHealth Hubs are expected to bring together multiple disciplines to advance the pace of scientific discovery, initially in one focal environmental or occupational health area.
Relevance to FIC Strategic Plan: The GEOHealth program supports the research capacity building of individuals, their institutions, and regional and global GEOHealth networks, fostering a sustainable platform to address priority needs in environmental and occupational health (Goal 1). The program supports activities that bring researchers and policy makers together to enhance uptake of evidence in policy and practice (Goal 3). The program focuses on the growing burden of noncommunicable diseases (Goal 4). The structure of the program fosters institutional research and training collaborations and benefits from several funding partnerships across the NIH, HHS, and internationally (Goal 5).
- Prüss-Ustün A, Wolf J, Corvalán C, Bos R and Neira M. 2016.
Preventing disease through healthy environments: A global assessment of the burden of disease from environmental risks. World Health Organization. ISBN 978 92 4 156519 6. Accessed 7 February 2019.
- International Labor Organization. 2012.
Estimating the Economic Costs of Occupational Injuries and Illnesses in Developing Countries: Essential Information for Decision-Makers. ISBN 978-92-2-127015-7. Accessed 7 February 2019.
- Rosenthal J, Jessup C, Felknor S, Humble M, Bader F, and Bridbord K. 2012.
International Environmental and Occupational Health: From Individual Scientists to Networked Science Hubs. Am J Ind Med 55:1069-1077. Accessed 7 February 2019.
Mobile Health: Technology and Outcomes in Low- and Middle-Income Countries
For the published request for applications, see the NIH Guide announcements:
Global Infectious Disease (GID) Planning Grant (D71)
For the published request for applications, see the NIH Guide announcements:
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