Malnutrition and Enteric Disease Study (MAL-ED)

Young girl standing on the doorstep in a doorway holds a large bowl
Photo by Felix Masi,
courtesy of Photoshare

Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development, abbreviated as MAL-ED and pronounced "mal-a-dee," is a five-year multi-site project to investigate the linkages between malnutrition and intestinal infections and their effects on children in the developing world. Fogarty's Division of International Epidemiology and Population Studies (DIEPS) serves as the Scientific Secretariat for this eight-site study located in Brazil, Peru, South Africa, Tanzania, India, Pakistan, Bangladesh and Nepal, and co-administers the study with the Foundation for NIH (FNIH). The program is funded by a grant of nearly $30 million from the Bill and Melinda Gates Foundation.

Roger Glass, M.D., Ph.D., of Fogarty, and Michael Gottlieb, Ph.D., of FNIH, serve as the Co-Principal Investigators in collaboration with other partners, including universities in the United States and foreign institutions.

MAL-ED News

Selected MAL-ED Publications

  • Enteroaggregative E. coli Subclinical Infection and co-Infections and Impaired Child Growth in the MAL-ED Cohort Study
    J Pediatr Gastroenterol Nutr. 2017 Sep 12
  • Epidemiology of enteroaggregative Escherichia coli infections and associated outcomes in the MAL-ED birth cohort.
    PLoS Negl Trop Dis. 2017 Jul 24
  • Measuring home environments across cultures: Invariance of the HOME scale across eight international sites from the MAL-ED study.
    J Sch Psychol. 2017 Oct
  • Infant Nutritional Status, Feeding Practices, Enteropathogen Exposure, Socioeconomic Status, and Illness Are Associated with Gut Barrier Function As Assessed by the Lactulose Mannitol Test in the MAL-ED Birth Cohort.
    Am J Trop Med Hyg. 2017 Jul
  • Age and Sex Normalization of Intestinal Permeability Measures for the Improved Assessment of Enteropathy in Infancy and Early Childhood: Results From the MAL-ED
    Study. J Pediatr Gastroenterol Nutr. 2017 Jul
  • Early Antibiotic Exposure in Low-resource Settings Is Associated With Increased Weight in the First Two Years of Life.
    J Pediatr Gastroenterol Nutr. 2017 Sep
  • Age and Sex Normalization of Intestinal Permeability Measures for the Improved Assessment of Enteropathy in Infancy and Early Childhood: Results from the MAL-ED Study.
    J Pediatr Gastroenterol Nutr. 2017 May 3
  • Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study.
    EBioMedicine. 2017 Apr
  • Determinants and Impact of Giardia Infection in the First 2 Years of Life in the MAL-ED Birth Cohort.
    J Pediatric Infect Dis Soc. 2017 Jun 1
  • Use of antibiotics in children younger than two years in eight countries: a prospective cohort study.
    Bull World Health Organ. 2017 Jan 1
  • Vaccine coverage and adherence to EPI schedules in eight resource poor settings in the MAL-ED cohort study.
    Vaccine. 2017 Jan 11
  • Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1-24 Months in the MAL-ED Study.
    Am J Trop Med Hyg. 2017 Feb 8
  • A Comparison of Diarrheal Severity Scores in the MAL-ED Multisite Community-Based Cohort Study.
    J Pediatr Gastroenterol Nutr. 2016 Nov
  • Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators. Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study.
    Clin Infect Dis. 2016 Nov 1
  • How multiple episodes of exclusive breastfeeding impact estimates of exclusive breastfeeding duration: report from the eight-site MAL-ED birth cohort study.
    Matern Child Nutr. 2016 Oct
  • Diarrheal disease and enteric infections in LMIC communities: how big is the problem?
    Trop Dis Travel Med Vaccines. 2016 Jul 19
  • Early interruption of exclusive breastfeeding: results from the eight-country MAL-ED
    study.
    J Health Popul Nutr. 2015 May 1

Updated January 26, 2018

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