Full Award: Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infants
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Global Brain Disorders Research
Project Information in NIH RePORTER
Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infants
Principal Institution
Massachusetts General Hospital
Principal Investigator(s) (PI)
Van Der Kouwe, Andre Jan Willem; Holmes, Martha; Kaba, Mamadou
Project Contact Information
Email: andre@nmr.mgh.harvard.edu
Year(s) Awarded
2017-2023
Country
South Africa
Collaborators
University of Cape Town
Stellenbosch University
University of San Diego
NIH Partners
NICHD
Project Description
Prevention of mother-to-child transmission (PMTCT) programs have very successfully reduced infant HIV infection by their mothers, leading to an increasing population of HIV-exposed, uninfected (HEU) infants. Despite being uninfected, these children experience increased illness, risk of neurodevelopmental delay, and mortality, compared to their unexposed peers. This project will investigate the relationship between maternal HIV infection, breast milk composition, the developing infant gut microbiome, and the developing infant brain. This project seeks to identify differences related to maternal HIV-infection that will provide insight into increased risks of HEU infants and reveal potential areas for targeted intervention to improve health and neurodevelopmental outcomes.
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