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Gut Microbiome and Regulation on Immune Responses in Guillain-barre Syndrome: A Prospective Controlled Study

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Global Brain Disorders Research

Project Information in NIH RePORTER

Gut Microbiome and Regulation on Immune Responses in Guillain-barre Syndrome: A Prospective Controlled Study

Principal Institution

International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B)

Principal Investigator(s) (PI)

Islam, Zhahirul

Project Contact Information

zislam@icddrb.org

Year(s) Awarded

2021–2023

Country

Bangladesh

Collaborators

Erasmus MC; University Medical Centre; the University of California; Johns Hopkins University; National Institute of Neurosciences & Hospital

Project Description

This research project will identify the Firmicutes rich species in gut microbiome in patients with Guillain-Barré syndrome (GBS) and determine the regulation of immune responses imposed by the host microbiome. The proposed study will provide new insight of gut-brain axis signaling to understand the role of gut microbiome through metagenomic approach and cellular expression of T and B cells repertoires, as well as correlate with clinical course and disease severity of GBS. The project will be a collaborative initiation between low- and middle-income countries (LMIC) and developed countries that enables to plan for mechanistic studies on gut microbiome regulation of immune responses for GBS patients to predict new therapeutic targets in future.

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