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US-UK Collab: Modelling reassortment at the cellular, clinical, and phylogenetic level in emerging Bunyaviruses

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Ecology and Evolution of Infectious Diseases (EEID)

Project Information in NIH RePORTER

US-UK Collab: Modelling reassortment at the cellular, clinical, and phylogenetic level in emerging Bunyaviruses

Principal Institution

Triad National Security, LLC

Principal Investigator(s) (PI)

Molina-Paris, Carmen

Project Contact Information

Email: molina-paris@lanl.gov

Year(s) Awarded

2021-2026

Country

Turkey; Tajikistan

NIH Partners

NIAID

Project Description

The overarching hypothesis of this project is that reassortment of segmented viruses plays a major role not only to drive their diversification and evolution, but to dramatically alter their ecology and transmission dynamics. Specifically, we aim to
    1. develop mathematical models of the intracellular life cycle for a family of segmented viruses to quantify for the first time their viral replication dynamics and reassortment frequencies
    2. develop standardised sequencing protocols and novel phylogenetic methods to quantify the evolutionary and epidemiological implications of reassortment for Crimean-Congo hemorrhagic fever virus (CCHFV).
    A biobank with clinical and field samples from CCHFV endemic regions in Turkey and Tajikistan will be set up in this project. Clinical and field data will be leveraged to ensure our methods and results have the potential to inform public health strategies, predict outbreak risk and contribute to the One Health approach for the prevention and control of Crimean-Congo hemorrhagic fever disease.

    Related World Regions / Countries