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Ecological and evolutionary causes and consequences of host heterogeneity induced by prior exposure

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Ecology and Evolution of Infectious Diseases (EEID)

Project Information in NIH RePORTER

Ecological and evolutionary causes and consequences of host heterogeneity induced by prior exposure

Principal Institution

Virginia Polytechnic Institute and State University

Principal Investigator(s) (PI)

Hawley, Dana M

Project Contact Information

Email: dana.hawley@vt.edu

Year(s) Awarded

2021–2025

NIH Partners

NIGMS

Project Description

Individual hosts vary in their susceptibility to pathogens, which has important consequences for outbreak dynamics and pathogen evolution. Our work will elucidate relationships between prior exposure of hosts to pathogens, as occurs naturally and via vaccination, and the degree of variability in host susceptibility. The models generated will be broadly useful for understanding and managing any pathogens, including those of humans, where host protection generated by prior exposure is variable, incomplete, or wanes over time.