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Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Emerging Global Leader

Project Information in NIH RePORTER

Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis

Principal Institution

Stellenbosch University Tygerberg Campus

Principal Investigator(s) (PI)

du Preez, Karen

Project Contact Information

Email: karen_dupreez@sun.ac.za

Year(s) Awarded

2020-2025

Country

South Africa

Project Description

Despite tuberculosis (TB) being a treatable and preventable disease, recent modeling work estimated that nearly 200,000 children <5 years died of TB during 2015, making it one of the top ten causes of death in children under 5 years globally. Unreliable and incomplete surveillance data for children with TB is a key challenge that currently limits our ability to appropriately manage children with this disease, including those suffering from severe forms such as TB meningitis (TBM) who experiences high mortality and often lifelong disability. This project will use interdisciplinary methods, including modelling and spatial analyses, to provide critical information on the burden, incidence and related mortality of TBM in children at a global, national and sub-national level in South Africa, whilst identifying opportunities to improve prevention and care through in- depth prospective surveillance.

Related World Regions / Countries

Related Global Health Research Topics