Development of an HIV infection model of human foreskin to obtain novel insights into virus transmission
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Development of an HIV infection model of human foreskin to obtain novel insights into virus transmission
Principal Institution
International Centre for Genetic Engineering and Biotechnology
Principal Investigator(s) (PI)
Chigorimbo-Tsikiwa, Nyaradzo Tsitsi
Project Contact Information
Email: nyaradzo.chigorimbo-tsikiwa@uct.ac.za
Year(s) Awarded
2020-2025
Country
South Africa
Collaborators
Cornell University
Ulm University
Project Description
This project will establish which HIV immune target cell populations found in the human foreskin can be infected with HIV-1. The objective is to identify molecular pathways and activation signals that determine this susceptibility and whether a male with an asymptomatic sexually transmitted infection has enhanced susceptibility. Repurposing interferon agonists will be assessed for activity as antivirals in human foreskin and other cells.
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