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Impact of asymptomatic sexually transmitted infections and interferon agonists on the susceptibility of foreskin primary cells to HIV‐1 infection

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Emerging Global Leader

Project Information in NIH RePORTER

Impact of asymptomatic sexually transmitted infections and interferon agonists on the susceptibility of foreskin primary cells to HIV-1 infection

Principal Institution

University of Cape Town

Principal Investigator(s) (PI)

Chigorimbo-Tsikiwa, Nyaradzo Tsitsi

Project Contact Information

Email: nyaradzo.chigorimbo-tsikiwa@uct.ac.za

Year(s) Awarded

2020-2025

Country

South Africa

Collaborators

Cornell University
Ulm University

Project Description

This project will establish which HIV immune target cell populations found in the human foreskin can be infected with HIV-1. The objective is to identify molecular pathways and activation signals that determine this susceptibility and whether a male with an asymptomatic sexually transmitted infection has enhanced susceptibility. Repurposing interferon agonists will be assessed for activity as antivirals in human foreskin and other cells.

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