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Dysregulation of the Human Ubiquitin Proteasome System in Pediatric Severe Malarial Anemia

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Emerging Global Leader

Project Information in NIH RePORTER

Dysregulation of the Human Ubiquitin Proteasome System in Pediatric Severe Malarial Anemia

Principal Institution

Maseno University

Principal Investigator(s) (PI)

Anyona, Samuel Bonuke

Project Contact Information

Email: sbonuke@gmail.com

Year(s) Awarded

2020-2024

Country

Kenya

Collaborators

University of New Mexico

Project Description

Children living in high transmission regions for Plasmodium falciparum, the most deadly malaria parasite, suffer from 61% of the malaria deaths, of which 93% occur in Africa. The main cause of severe disease and death in these children is from profoundly low hemoglobin (Hb<5.0g/dL) levels, classified as severe malarial anemia (SMA). This project aims to study the human ubiquitin proteasome system (UPS) which is an important pathway for host-pathogen interactions, yet remains unexplored in human malaria, including in Kenyan children who will be the focus of the studies.

Related World Regions / Countries

Related Global Health Research Topics