Clonotyping Airway T-cells to Uncover Microbiome-Specific Inflammotypes in HIV-associated COPD
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
Emerging Global Leader
Project Information in NIH RePORTER
Clonotyping Airway T-cells to Uncover Microbiome-Specific Inflammotypes in HIV-associated COPD
Principal Institution
Makerere University Lung Institute Limited
Principal Investigator(s) (PI)
Kayongo, Alex
Project Contact Information
alexkayongo@gmail.com
Year(s) Awarded
2025-2030
Country
Regional - Sub-Saharan Africa
Collaborators
Imperial College London
Charite University
Project Description
Sub-Saharan Africa, with the highest density of people living with HIV, has experienced dramatic increases in COPD mortality, driven by persistent airway inflammation, despite virologic suppression. Mechanistically, the drivers of this persistent inflammation are not fully known. In this project we will characterise airway microbiome-induced immune responses to underpin specific microbiome-immune signatures (referred to as inflammotypes) driving persistent inflammation in COPD among HIV-infected individuals in a rural Ugandan cohort.
Related World Regions / Countries
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