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Oxygen sensing mechanism(s) in fetal programming of salt-sensitive hypertension

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Emerging Global Leader

Project Information in NIH RePORTER

Oxygen sensing mechanism(s) in fetal programming of salt-sensitive hypertension

Principal Institution

University of Lagos College of Medicine

Principal Investigator(s) (PI)

Oloyo, Ahmed Kolade

Project Contact Information

Email: akoloyo@cmul.edu.ng

Year(s) Awarded

2019-2024

Country

Nigeria

Collaborators

Texas Southern University

Project Description

Heritability of salt-sensitive hypertension and susceptibility of offspring to maternal exposure to high dietary salt during pregnancy suggests that hypertension has its origin in early life, but how maternal exposure to perinatal high salt diet programs the offspring to develop salt-sensitive hypertension in adulthood is not clear. This study investigates the interactions between increased tissue oxygen demand effect of a high salt diet and the low oxygen tension environment in-utero in the fetal programming of salt sensitive hypertension as the source of the early origin of salt-sensitive hypertension. Investigating the mechanism(s) underlying the early origin of salt- sensitive hypertension will improve the understanding of its pathophysiology and increase the chances of discovering a new and more effective therapy for the disease.

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