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Investigation of responses to Mycobacterium tuberculosis complex lineages by different African host population: Implications for host-directed therapies

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Emerging Global Leader

Project Information in NIH RePORTER

Investigation of responses to Mycobacterium tuberculosis complex lineages by different African host population: Implications for host-directed therapies

Principal Institution

Medical Research Labs - Gambia

Principal Investigator(s) (PI)

Tientcheu Djomkam, Leopold

Project Contact Information

Email: tientcheuleo@gmail.com

Year(s) Awarded

2018–2023

Country

Gambia

Collaborators

Emory University

Project Description

The overall aim of this project is to inform the development of host-directed therapeutics for tuberculosis (TB)  in Africa where there is epidemiological evidence of differences in disease pattern, bacterial strains and human genetic diversity affecting the outcome of treatment. The results generated from the two African TB-endemic regions will improve our understanding of how new immunomodulatory molecules will work and propose novel host targets for host-directed therapies (HDT) accounting for existing human and bacterial population diversity. 

Related World Regions / Countries

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