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Host Defense Against Shigella Flexneri

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Emerging Global Leader

Project Information in NIH RePORTER

Host Defense Against Shigella Flexneri

Principal Institution

International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)

Principal Investigator(s) (PI)

Noor, Zannatun

Project Contact Information

Email: zannatun@icddrb.org

Year(s) Awarded

2019–2024

Country

Bangladesh

Collaborators

University of Virginia

Project Description

Approximately 165 million cases of shigellosis are annually reported in low-income countries, with at least 1 million of these cases resulting in death, especially in children under five years of age. Very recently, Shigella ranked the highest among the overall pathogen burden, with particularly high incidence in the second year of life. We propose to advance the understanding of host response to Shigella flexneri infection to lay the foundation for developing potential host-targeted treatment for this highly antibiotic-resistant bacterium.

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