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Psychosocial Distress, Inflammatory Reactivity and Central Sensitization in the Pathway to HIV-Related Pain: Characterizing the Associations and Developing a Pragmatic, Coping-Focused Intervention

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

Emerging Global Leader

Project Information in NIH RePORTER

Psychosocial Distress, Inflammatory Reactivity and Central Sensitization in the Pathway to HIV-Related Pain: Characterizing the Associations and Developing a Pragmatic, Coping-Focused Intervention

Principal Institution

University of Cape Town

Principal Investigator(s) (PI)

Madden, Victoria Joy

Project Contact Information

Email: tory.maddden@uct.ac.za

Year(s) Awarded

2019–2024

Country

South Africa

Collaborators

Brigham and Women's Hospital

Project Description

HIV-related pain is under-recognised, distressing, poorly understood, and difficult to treat, yet clarifying the mechanistic pathways underlying HIV-related pain would inform treatment development. This project will study the relationships between psychosocial distress, inflammatory reactivity, central sensitization, and HIV-related pain and develop a pragmatic, coping-focused interventions to decrease distress and pain in people with HIV. This research is of considerable public health importance to countries with high and low burdens of HIV because it stands to inform treatments to decrease HIV-related pain and thus relieve the considerable strain that HIV-related pain places on healthcare services.

Related World Regions / Countries

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