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Cardiometabolic Outcomes, Mechanisms and approach to prevention of Dolutegravir Associated Weight Gain In South Africa

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

HIV-associated Noncommunicable Diseases Research at LMIC Institutions

Project Information in NIH RePORTER

Cardiometabolic Outcomes, Mechanisms and approach to prevention of Dolutegravir Associated Weight Gain In South Africa

Principal Institution

University of Pittsburgh

Principal Investigator(s) (PI)

Nachega, Jean Bisimwa; Kengne, Andre Pascal

Project Contact Information

jbn16@pitt.edu

Year(s) Awarded

2020–2022

Country

South Africa

Project Description

DTG-based ART regimens are poised to become the backbone for contemporary ART in South Africa, where the vast majority of PLWH reside. Our project study focuses on the not only the effects of dolutegravir on weight gain, changes in body composition and fat distribution, accumulation of liver fat, and blood markers of cardiometabolic risk, but the feasibility of a possible intervention. Our study will therefore provide critical data that will elucidate the mechanisms and health consequences of DTG-associated weight gain to inform the development of screening/prevention strategies, which could influence clinical practice and be implemented and scaled-up globally for PLWH on DTG-containing ART regimens.

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