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Investigating the role of altered lung microbiome in fueling Th17 mediated airway inflammation in COPD among HIV-infected individual

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

HIV-associated Noncommunicable Diseases Research at LMIC Institutions

Project Information in NIH RePORTER

Investigating the role of altered lung microbiome in fueling Th17 mediated airway inflammation in COPD among HIV-infected individual

Principal Institution

Makerere University

Principal Investigator(s) (PI)

Kayongo, Alex

Project Contact Information

Email: alexkayongo@gmail.com

Year(s) Awarded

2022–2024

Country

Uganda

Project Description

In this project, we will determine the association between lung microbiome and immune responses (particularly Th17/Treg responses) in the back of the lungs (distal airways) of people living with HIV (PLWH) with chronic obstructive pulmonary disease (COPD) in a controlled Ugandan cohort using bronchoalveolar lavage (BAL). Also called bronchoalveolar washing, BAL is used to collect a sample from the lungs for testing. 

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