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Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).
Funding Fogarty Program
HIV-associated Noncommunicable Diseases Research at LMIC Institutions
Project Information in NIH RePORTER
Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
Principal Institution
Stellenbosch University
Principal Investigator(s) (PI)
Decloedt, Eric Hermann; Orrell, Catherine
Project Contact Information
Email:
ericdecloedt@sun.ac.za
Year(s) Awarded
2023–2025
Country
South Africa
NIH Partners
OD/NIH
Project Description
The risk for stroke is two-fold higher in people with HIV (PWH) compared to people without HIV, despite antiretroviral therapy (ART) and viral suppression, and without many of the traditional stroke risk factors, suggesting ongoing HIV-associated inflammation as a potential driver of stroke risk. Adherence to ART sufficient to suppress viral loads to below the clinically-relevant threshold of 200 copies/mL may not be adequate to suppress viremia completely, with ongoing HIV-associated inflammation.
This project will conduct a comparative observational study in virally suppressed PWH presenting with stroke compared to PWH without stroke to obtain preliminary, exploratory data on the association between stroke and imperfect adherence to ART, viremia and the viral reservoir, and exploratory proteomic biomarkers.
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