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Developing Clinical Prediction Tools to Define Strategies for Differentiated Service Delivery in Children and Adolescents Living with HIV in sub-Saharan Africa

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

International Research Scientist Development Award (IRSDA)

Project Information in NIH RePORTER

Developing Clinical Prediction Tools to Define Strategies for Differentiated Service Delivery in Children and Adolescents Living with HIV in sub-Saharan Africa

Principal Institution

Baylor College of Medicine

Principal Investigator(s) (PI)

Kay, Alexander William

Project Contact Information

Email: Alexander.Kay@bcm.edu

Year(s) Awarded

2020–2025

Country

Eswatini; Lesotho; Malawi; Tanzania; Uganda

Collaborators

Children's Center of Excellenece ‐ eSwatini

Project Description

A public health approach to the management of children and adolescents living with HIV in sub-Saharan Africa has increased access to care but there remains a need for differentiated service delivery with intensified treatment and supportive strategies for children at higher risk of adverse outcomes. The clinical predication tools developed in this study will identify children at risk a priori and avert unnecessary morbidity and mortality. This project will also define risk factors for tuberculosis (TB) disease in children living with HIV, identify those most likely to benefit from TB preventive therapy, and estimate the risk reduction associated with three different preventive therapy approaches; this knowledge will guide the design of prospective studies to investigate shorter tuberculosis preventive therapy regimens and inform evidence-based TB preventive therapy strategies.

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