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Modulatory Effects of the Functional Gut Microbiome in Relation to Cassava Associated Motor and Neurocognitive Deficits

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

International Research Scientist Development Award (IRSDA)

Project Information in NIH RePORTER

Modulatory Effects of the Functional Gut Microbiome in Relation to Cassava Associated Motor and Neurocognitive Deficits

Principal Institution

Children's Research Institute

Principal Investigator(s) (PI)

Bramble, Matthew Scott

Project Contact Information

Email: mbramble@ucla.edu

Year(s) Awarded

2021-2026

Country

Regional - Sub-Saharan Africa

Project Description

Women and children in sub-Saharan Africa who have a chronic dietary reliance on toxic cyanogenic cassava are at heightened risk for the development of cassava neurotoxicity, leading to a debilitating disease with severe physical and cognitive impairments known as konzo. While factors such as nutrition, toxicity dose, water access, and other environmental factors are associated with the development of konzo, the exact molecular mechanisms that contribute to disease pathogenesis remain largely unknown, despite large global health significance.

This project aims to determine the likely modulatory role of the gut microbiome by elucidating differences in composition and functionality in regards to host-microbiome metabolism between disease discordant siblings, leading to a deeper understanding of susceptibility and potential monitoring and preventative solutions.


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