U.S. flag

An official website of the United States government

NIH: Fogarty International Center NIH: Fogarty International Center
Advancing Science for Global Health
Advancing Science for Global Health
Home > Grants > Search Current & Recent Grants > Global Hypomethylation Biomarkers for Cervical Cancer Screening in Women Living with HIV in LMICs Print

Global Hypomethylation Biomarkers for Cervical Cancer Screening in Women Living with HIV in LMICs

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

HIV-associated Noncommunicable Diseases Research at LMIC Institutions

Project Information in NIH RePORTER

Global Hypomethylation Biomarkers for Cervical Cancer Screening in Women Living with HIV in LMICs

Principal Institution

Northwestern University at Chicago

Principal Investigator(s) (PI)

Zheng, Yinan; Silas, Olugbenga Akindele

Project Contact Information

y-zheng@northwestern.edu

Year(s) Awarded

2021–2023

Country

Nigeria; Tanzania

Project Description

This study aims to study novel global DNA methylation aberrations, a hallmark of cancer, in cervical cancer women with HIV infection in two African countries, i.e., Nigeria in West Africa and Tanzania in East Africa. Our results will not only provide new mechanistic insight into HIV-associated cervical cancer, our unique study population and study design will also allow up to test the feasibility and clinical utility of the identified biomarkers as a first-line screening tool for HIV-infected women and in conjunction with Pap smear practice. Our study will promote the development of economic and effective cervical cancer screening tools for early detection and treatment of cervical precancerous abnormalities among HIV- infected women in low- and middle-income countries.

Related World Regions / Countries

Related Global Health Research Topics