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The Impact of HIV on the Breast Cancer Tumor Microenvironment

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

HIV-associated Noncommunicable Diseases Research at LMIC Institutions

Project Information in NIH RePORTER

The Impact of HIV on the Breast Cancer Tumor Microenvironment

Principal Institution

Fred Hutchinson Cancer Research Center

Principal Investigator(s) (PI)

Menon, Manoj P.

Project Contact Information

mmenon@fredhutch.org

Year(s) Awarded

2021–2023

Country

Uganda

Project Description

Based at the Uganda Cancer Institute – Fred Hutch Cancer Centre (UCI-FHCC) in Kampala, Uganda and the Fred Hutch Cancer Research Center in Seattle, Washington, we aim to conduct research to define drivers and actionable effects of HIV and associated immune dysregulation in the tumor niche in breast cancers in women living with HIV (WLWH). We will perform integrated immune profiling, and genomic studies to define mechanisms by which persistent HIV and associated immune abnormalities shape the tumor microenvironment (TME) and inhibit tumor immune surveillance and immune control. Our research aims to translate discoveries about HIV-associated immune dysfunction in the TME into testable hypotheses for novel immune-based approaches for the prevention and treatment of breast cancers for WLWH in sub-Saharan Africa.

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