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Understanding Methotrexate Dosing, Pharmacokinetics, and Toxicities for Burkitt Lymphoma in Malawi

The following grant was awarded by, is supported by, is administered by or is in partnership with the Fogarty International Center at the U.S. National Institutes of Health (NIH).

Funding Fogarty Program

International Research Scientist Development Award (IRSDA)

Project Information in NIH RePORTER

Understanding Methotrexate Dosing, Pharmacokinetics, and Toxicities for Burkitt Lymphoma in Malawi

Principal Institution

University of North Carolina Chapel Hill

Principal Investigator(s) (PI)

Westmoreland, Katherine Douglas

Project Contact Information

Email: kawestmo@email.unc.edu

Year(s) Awarded

2019-2024

Country

Malawi

Collaborators

UNC Project Malawi

NIH Partners

NCI

Project Description

Burkitt lymphoma is the commonest cancer among children, adolescents, and young adults (AYA) in sub-Saharan Africa (SSA), and survival rates are dismal compared to resource-rich settings. This project focuses on improved understanding of chemotherapy pharmacokinetics (the movement of drugs within the body) and patient-reported health-related quality of life outcomes in this unique population, integrated within a rigorously conducted prospective clinical trial, to optimize treatment regimens and improve survival.

Related World Regions / Countries

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